Absorption of 5-aminosalicylic acid from colon and rectum.
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چکیده
منابع مشابه
Electrochemical Synthesis of 5-Aminosalicylic Acid from 5- Nitrosalicylic Acid in Alkaline Media
5-Aminosalicylic acid (5-ASA) is currently prepared by electrochemical reduction of 5-nitrosalicylic acid (5-NSA) in acidic media. In this work, electrolytic reduction of 5-NSA in alkaline media is presented. Reactionconditions and parameters such as anode and cathode electrodes, electrolyte type, reaction time, temperature,current, and the pH for isolation of product are investigated. The yiel...
متن کاملNephrotoxic lesions from 5-aminosalicylic Acid.
5-Aminosalicylic acid given to rats as a single intravenous injection led to necrosis of the proximal convoluted tubules and of the renal papilla. These two lesions developed at the same time and the cortical lesions did not appear to be a consequence of the renal papillary necrosis. Since the compound possesses the molecular structure both of a phenacetin derivative and of a salicylate these o...
متن کاملelectrochemical synthesis of 5-aminosalicylic acid from 5- nitrosalicylic acid in alkaline media
5-aminosalicylic acid (5-asa) is currently prepared by electrochemical reduction of 5-nitrosalicylic acid (5-nsa) in acidic media. in this work, electrolytic reduction of 5-nsa in alkaline media is presented. reactionconditions and parameters such as anode and cathode electrodes, electrolyte type, reaction time, temperature,current, and the ph for isolation of product are investigated. the yiel...
متن کاملEster Prodrug of 5-Aminosalicylic Acid for Colon Specific Drug Delivery: Synthesis, Kinetics, Hydrolysis and Stabilities
Acrylic type polymeric systems having degradable ester bonds linked to the 5-aminosalicylic acid (5-ASA), were synthesized and evaluated for colon targeted drug delivery. The obtained prodrug was characterized by FTIR,HNMR,Melting point and Rf value.In vitro drug release study was conducted at pH 1.2,7.4 and in rat fecal matter. Drug release in rat fecal matter at pH 7.4 was found to be most sa...
متن کامل5-aminosalicylic acid prevents oxidant mediated damage of glyceraldehyde-3-phosphate dehydrogenase in colon epithelial cells.
BACKGROUND Reactive oxygen and nitrogen derived species produced by activated neutrophils have been implicated in the damage of mucosal proteins including the inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in the active inflammatory lesion in patients with inflammatory bowel disease (IBD). This study investigated the efficacy of currently used IBD therapeutics to prevent injury ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1988
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1988.tb03301.x